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KMID : 0043320180410020184
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Archives of Pharmacal Research
2018 Volume.41 No. 2 p.184 ~ p.191
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Pyrazinone derivatives from the coral-derived Aspergillus ochraceus LCJ11-102 under high iodide salt
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Peng Xiaoping
Wang Yi
Zhu Tonghan
Zhu Weiming
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Abstract
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Five new pyrazin-2(1H)-one derivatives, ochramides A?D (1?4) and ochralate A (5), as well as three known analogues (6?8) were isolated from the fermentation broth of the marine coral-derived halotolerant Aspergillus ochraceus LCJ11-102 in a nutrient-limited medium containing 10% NaI. Their chemical structures were determined by analyzing NMR and X-ray diffraction data. Compounds 2, 5 and 6 showed antimicrobial activities against Enterobacter aerogenes with the MIC values of 40.0, 18.9, and 20.1 μM, respectively.
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KEYWORD
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Coral, Halotolerant fungus, Aspergillus ochraceus, Antibacterial activity, Aluminum chelates
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